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Annotation

Annotation#

Topic overview#

In this lesson you will learn about the concept of sequence annotation. You will learn (i) how to predict genes from genome sequences, (ii) how to predict their function by homology to genes from other organisms and the databases that we use to do this, and (iii) how to automate this process.

Learning objectives#

Learning objective 1 - You can predict genes from genome sequences

  • LO 1.1 - You understand the concept of reading frames in genome sequences

  • LO 1.2 - You can use command line tools to predict open reading frames (ORFs) in bacterial genomes

Learning objective 2 - You can predict gene function

  • LO 2.1 - You understand the concept of conserved domains in proteins

  • LO 2.2 - You understand the homology-based function annotation of proteins

  • LO 2.3 - You learn about important DNA/protein sequence databases and their differences in quality and evidence provided

  • LO 2.4 - You can predict gene function with web based tools

Learning objective 3 - You can automate gene function prediction

  • LO 3.1 - You can use command line tools to perform automated gene function prediction

Contents